Prospecting In Vitro Antioxidant and Photoprotective Properties of Rosmarinic Acid in a Sunscreen System Developed by QbD Containing Octyl p-Methoxycinnamate and Bemotrizinol

Progressively growing diagnoses of skin cancer trigger public health concerns about excessive sun exposure, awareness the deleterious effects ultraviolet (UV) radiation on skin, and proper use sunscreens. Studies show that bioactive molecules, such as rosmarinic acid (RA), may potentiate photoprotective antioxidant activity topical formulations. This research presents application concepts quality by design (QbD) to evaluate critical parameters development an optimized cosmetic formulation with RA means understanding product space. Samples were developed using experiments (DoE) they evaluated for in vitro efficacy, well photostability through artificial irradiation. We able achieve performance regarding SPF properties experiments. obtained equations predicting SPF. Considering our sunscreen system, octyl p-methoxycinnamate bemotrizinol, presence increased its capacity; however, was reduced when both UV filters used. The multifunctional sunscreens is utmost importance; moreover, there a need rational formulations ensure representative statistical tests interactions among components desired attributes, including efficacy.